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Credit: Pixabay/CC0 Public Domain Researchers at Penn Medicine have identified specific brain circuits that are impacted by psilocybin—the active compound found in some psychedelic mushrooms—which could lead to new paths forward for pain and mental health management options. Chronic pain affects more than 1.5 billion people worldwide and is often deeply entangled with depression and…
Regulation of psilocybin — the “magic” substance in psychedelic mushrooms — has been a hot-button issue for Californians in recent years, but repeated attempts by state lawmakers to allow medical use of the substance have floundered.Now it seems change may come at the federal level.The U.S. Department of Health and Human Services is weighing a…
(Image credit: Yana Iskayeva via Getty Images) DENVER—Psilocybin, the main psychoactive ingredient in magic mushrooms, can alleviate depression for at least five years after a single dose, a new study finds.The research, presented June 18 at the Psychedelic Science 2025 conference in Denver, focused on patients with major depressive disorder (MDD), which is often called…
New results from a clinical trial reveal that a single dose of psilocybin — a naturally occurring psychedelic compound found in mushrooms — can provide sustained reductions in depression and anxiety in individuals with cancer suffering from major depressive disorder. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American…
Researchers at Mass General Brigham discovered that interactions between immune cells and brain cells play a key role in triggering fear responses. However, treatments with psychedelics such as MDMA and psilocybin may help reverse these effects. Researchers at Mass General Brigham have discovered that interactions between the immune system and brain cells play a critical…
More Americans are using psilocybin, the hallucinogenic compound found in psychedelic mushrooms.A report published Monday in the journal Annals of Internal Medicine found psilocybin use has been rising since 2019, after remaining relatively stable for years. “That tells us something is changing,” said Kari Rockhill, an epidemiologist and assistant statistical scientist at Rocky Mountain Poison &…